|
KMID : 1103920110170010061
|
|
Korean Journal of Hepatology
2011 Volume.17 No. 1 p.61 ~ p.65
|
|
|
Vogt-Koyanagi-Harada disease occurring during pegylated interferon-α2b and ribavirin combination therapy for chronic hepatitis C
|
|
Lim Jae-Hee
Lee Yun-Nah
Kim Young-Seok
Kim Sang-Gyune
Jeong Seung-Won
Jang Jae-Young
Kim Hong-Soo
Lee Sae-Hwan
Park Tae-Kwann
|
|
|
Abstract
|
|
|
|
Vogt-Koyanagi-Harada (VKH) disease is a multisystem syndrome characterized by ocular (uveitis and retinal detachment), neurological (headache, tinnitus, and meningitis), and integumentary (vitiligo, alopecia, and poliosis) involvement. Although the pathogenesis of VKH disease is not well understood, an autoimmune T-cell response to a melanocyte-associated antigen is considered to be a cause of VKH disease. The complex immunological response to interferon and ribavirin may induce or exacerbate the autoimmune condition; however, VKH disease is a very rare complication associated with interferon therapy in chronic hepatitis C. We report a case of VKH disease occurring during pegylated interferon-α2b and ribavirin combination therapy for chronic hepatitis C.
|
|
|
KEYWORD
|
|
|
Vogt-Koyanagi-Harada disease, Interferon-α2b, Chronic hepatitis C
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
   
|